Biomedicines, Free Full-Text
Por um escritor misterioso
Last updated 13 julho 2024
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic of coronavirus disease in 2019 (COVID-19). Genome surveillance is a key method to track the spread of SARS-CoV-2 variants. Genetic diversity and evolution of SARS-CoV-2 were analyzed based on 260,673 whole-genome sequences, which were sampled from 62 countries between 24 December 2019 and 12 January 2021. We found that amino acid (AA) substitutions were observed in all SARS-CoV-2 proteins, and the top six proteins with the highest substitution rates were ORF10, nucleocapsid, ORF3a, spike glycoprotein, RNA-dependent RNA polymerase, and ORF8. Among 25,629 amino acid substitutions at 8484 polymorphic sites across the coding region of the SARS-CoV-2 genome, the D614G (93.88%) variant in spike and the P323L (93.74%) variant in RNA-dependent RNA polymerase were the dominant variants on six continents. As of January 2021, the genomic sequences of SARS-CoV-2 could be divided into at least 12 different clades. Distributions of SARS-CoV-2 clades were featured with temporal and geographical dynamics on six continents. Overall, this large-scale analysis provides a detailed mapping of SARS-CoV-2 variants in different geographic areas at different time points, highlighting the importance of evaluating highly prevalent variants in the development of SARS-CoV-2 antiviral drugs and vaccines.
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Biomedicines (ISSN 2227-9059, IF: 6.081) Questionnaire: Participate in the 10th Anniversary Online Survey Now
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Full article: Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action
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Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients
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Biopsy-free in vivo virtual histology of skin using deep learning
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Biomedicines, Free Full-Text
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Biomedicines An Open Access Journal from MDPI
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Decoding the Patterns of Self and Nonself by the Innate Immune System
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An overview on nanoparticles used in biomedicine and their cytotoxicity - ScienceDirect
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Articles by Sajjad Ahmad's Profile, Freelance Journalist
Boxplots for illustration of cell numbers in stimulated and
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Biomedicines An Open Access Journal from MDPI
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Long COVID: pathophysiological factors and abnormalities of coagulation: Trends in Endocrinology & Metabolism
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Nanobodies as a powerful platform for biomedicine: Trends in Molecular Medicine
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