Brain Sciences, Free Full-Text
Por um escritor misterioso
Last updated 05 julho 2024
![Brain Sciences, Free Full-Text](https://www.mdpi.com/brainsci/brainsci-11-01411/article_deploy/html/images/brainsci-11-01411-g004-550.jpg)
Neuroinflammation is often accompanied by central nervous system (CNS) injury seen in various CNS diseases, with no specific treatment. Drug repurposing is a strategy of finding new uses for approved or investigational drugs, and can be enabled by the Library of Integrated Network-based Cellular Signatures (LINCS), a large drug perturbation database. In this study, the signatures of Lipopolysaccharide (LPS) were compared with the signatures of compounds contained in the LINCS dataset. To the top 100 compounds obtained, the Quantitative Structure-Activity Relationship (QSAR)-based tool admetSAR was used to identify the top 10 candidate compounds with relatively high blood–brain barrier (BBB) penetration. Furthermore, the seventh-ranked compound, dutasteride, a 5-α-reductase inhibitor, was selected for in vitro and in vivo validation of its anti-neuroinflammation activity. The results showed that dutasteride significantly reduced the levels of IL-6 and TNF-α in the supernatants of LPS-stimulated BV2 cells, and decreased the levels of IL-6 in the hippocampus and plasma, and the number of activated microglia in the brain of LPS administration mice. Furthermore, dutasteride also attenuated the cognitive impairment caused by LPS stimulation in mice. Taken together, this study demonstrates that the LINCS dataset-based drug repurposing strategy is an effective approach, and the predicted candidate, dutasteride, has the potential to ameliorate LPS-induced neuroinflammation and cognitive impairment.
![Brain Sciences, Free Full-Text](https://pub.mdpi-res.com/brainsci/brainsci-13-01128/article_deploy/html/images/brainsci-13-01128-g001-550.jpg?1690359866)
Wisconsin Card Sorting Test For Windows Download - Colaboratory
![Brain Sciences, Free Full-Text](https://www.mdpi.com/brainsci/brainsci-03-00877/article_deploy/html/images/brainsci-03-00877-g001-1024.png)
Brain Sciences, Free Full-Text
Reading in the brain : the new science of how we read : Dehaene
Brain Sciences An Open Access Journal from MDPI
![Brain Sciences, Free Full-Text](https://pub.mdpi-res.com/title_story/title_story_16998380314615.jpg?1702894284)
Brain Sciences An Open Access Journal from MDPI
![Brain Sciences, Free Full-Text](https://image.isu.pub/230525200811-97bdd9387c60f991adcd0e88e61d04ab/jpg/page_1.jpg)
The Brain That Changes Itself Audiobook Free Complete Version
![Brain Sciences, Free Full-Text](https://www.mdpi.com/brainsci/brainsci-13-00045/article_deploy/html/images/brainsci-13-00045-g001-550.jpg)
Sharp Network Scanner Tool Version 3.2 - Colaboratory
![Brain Sciences, Free Full-Text](https://learnbright.org/wp-content/uploads/2022/06/Human-Brain-Title-Page.jpg)
Human Brain, Free PDF Download - Learn Bright
![Brain Sciences, Free Full-Text](https://pub.mdpi-res.com/brainsci/brainsci-13-01713/article_deploy/html/images/brainsci-13-01713-g001-550.jpg?1702446848)
Brain Sciences An Open Access Journal from MDPI
![Brain Sciences, Free Full-Text](https://cyberleninka.org/viewer_images/204451/f/1.png)
Three distinct co-existent primary brain tumors in a patient
![Brain Sciences, Free Full-Text](https://external-preview.redd.it/brain-sciences-free-full-text-toxicity-of-synthetic-v0-b7tzTeNyst6Ax5n_jUyNvaVZ51RgSGkoP8GWPoeKRVs.jpg?auto=webp&s=caff6663ce6aea1557596741a73cdf0493063576)
Brain Sciences, Free Full-Text
![Brain Sciences, Free Full-Text](https://pbs.twimg.com/media/FLAmr5laIAYJtqf.jpg)
PDF* Free Read Uncommon Sense Teaching: Practical Insights in
Recomendado para você
-
brain test Archives - Page 8 of 2805 julho 2024
-
Lengkap Ada Video, Brain Test Level 411 Sang Ksatria Harus05 julho 2024
-
Brain test lösung level 411|TikTok Search05 julho 2024
-
Brain Teaser: 14+7-4=11 Can You Move 3 Matchsticks To Fix The05 julho 2024
-
Hashimoto's 411 - Ten years ago I was sick. Really sick. I thought05 julho 2024
-
Psych Mnemonics 411 Free Download05 julho 2024
-
Long-term exposure to 835 MHz RF-EMF induces hyperactivity05 julho 2024
-
Frontiers The brain-body disconnect: A somatic sensory basis for05 julho 2024
-
Alterations in homologous recombination repair genes in prostate05 julho 2024
-
Biosynthesis of Argolaphos Illuminates the Unusual Biochemical05 julho 2024
você pode gostar
-
Thor: Love and Thunder Post-Credits Scene Introduces a Major MCU Hero05 julho 2024
-
roupas de hacha club soft|Pesquisa do TikTok05 julho 2024
-
LEGAL!!) FREE ROBUX GENERATOR NO HUMAN VERIFICATION 2022 [ GrAD]05 julho 2024
-
72 Park Miami Beach Condo05 julho 2024
-
Gogeta blue evolution vs Gogeta ssj 4 limit breaker#gogetablue05 julho 2024
-
v on X: only Ellie can pull off this haircut Eren look musty as fuck with the Karen cut / X05 julho 2024
-
Tomb Raider: A ordem cronológica dos games! - Gamers & Games05 julho 2024
-
Stick Fight The Game Download BEST Mac - Collection05 julho 2024
-
Common Core Question Stems 11th and 12th Grade ELA - Language by05 julho 2024
-
Chess on Bitcoin? Meet PowChess - CoinGeek05 julho 2024