Cancers, Free Full-Text
Por um escritor misterioso
Last updated 28 julho 2024
![Cancers, Free Full-Text](https://pub.mdpi-res.com/cancers/cancers-14-00976/article_deploy/html/images/cancers-14-00976-g001.png?1645093936)
Emerging evidence suggests that a small subpopulation of cancer stem cells (CSCs) is responsible for initiation, progression, and metastasis cascade in tumors. CSCs share characteristics with normal stem cells, i.e., self-renewal and differentiation potential, suggesting that they can drive cancer progression. Consequently, targeting CSCs to prevent tumor growth or regrowth might offer a chance to lead the fight against cancer. CSCs create their niche, a specific area within tissue with a unique microenvironment that sustains their vital functions. Interactions between CSCs and their niches play a critical role in regulating CSCs’ self-renewal and tumorigenesis. Differences observed in the frequency of CSCs, due to the phenotypic plasticity of many cancer cells, remain a challenge in cancer therapeutics, since CSCs can modulate their transcriptional activities into a more stem-like state to protect themselves from destruction. This plasticity represents an essential step for future therapeutic approaches. Regarding self-renewal, CSCs are modulated by the same molecular pathways found in normal stem cells, such as Wnt/β-catenin signaling, Notch signaling, and Hedgehog signaling. Another key characteristic of CSCs is their resistance to standard chemotherapy and radiotherapy treatments, due to their capacity to rest in a quiescent state. This review will analyze the primary mechanisms involved in CSC tumorigenesis, with particular attention to the roles of CSCs in tumor progression in benign and malignant diseases; and will examine future perspectives on the identification of new markers to better control tumorigenesis, as well as dissecting the metastasis process.
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Rare Cancer Day - National Organization for Rare Disorders
![Cancers, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2021/nejm_2021.385.issue-20/nejmoa2112435/20211108/images/img_medium/nejmoa2112435_f0.jpeg)
Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer
![Cancers, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2003/nejm_2003.349.issue-19/nejmoa032312/production/images/img_medium/nejmoa032312_f1.jpeg)
A Randomized Trial of Letrozole in Postmenopausal Women after Five Years of Tamoxifen Therapy for Early-Stage Breast Cancer
![Cancers, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2021/nejm_2021.384.issue-25/nejmoa2103695/20211129/images/img_medium/nejmoa2103695_f0.jpeg)
Sotorasib for Lung Cancers with KRAS p.G12C Mutation
Detection of HPV-16 DNA by PCR in histologically cancer free lymph nodes from patients with cervical cancer. - Abstract - Europe PMC
![Cancers, Free Full-Text](http://www.jshbps.jp/uploads/images/22-3.jpg)
Classification of biliary tract cancers established by JSHBPS: 3rd English edition|Japanese Society of Hepato-Biliary-Pancreatic Surgery
![Cancers, Free Full-Text](https://cyberleninka.org/viewer_images/513350/f/1.png)
Hypercalcemia and treated breast cancers: The diagnostic dilemma – topic of research paper in Clinical medicine. Download scholarly article PDF and read for free on CyberLeninka open science hub.
![Cancers, Free Full-Text](https://www.mdpi.com/cancers/cancers-14-03441/article_deploy/html/images/cancers-14-03441-g001-550.jpg)
Loco Evolution Binary Patch - Colaboratory
![Cancers, Free Full-Text](https://nci-media.cancer.gov/pdq/media/images/598469.jpg)
Skin Cancer Types, Symptoms and Information
![Cancers, Free Full-Text](https://www.pnas.org/cms/asset/07a9a7ac-b058-419a-acf5-a724cae717b1/keyimage.jpg)
Noninvasive detection of any-stage cancer using free glycosaminoglycans
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Radical causes of cancer
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