Cells, Free Full-Text
Por um escritor misterioso
Last updated 01 agosto 2024
Community-acquired pneumonia remains a major contributor to global communicable disease-mediated mortality. Neutrophils play a leading role in trying to contain bacterial lung infection, but they also drive detrimental pulmonary inflammation, when dysregulated. Here we aimed at understanding the role of microRNA-223 in orchestrating pulmonary inflammation during pneumococcal pneumonia. Serum microRNA-223 was measured in patients with pneumococcal pneumonia and in healthy subjects. Pulmonary inflammation in wild-type and microRNA-223-knockout mice was assessed in terms of disease course, histopathology, cellular recruitment and evaluation of inflammatory protein and gene signatures following pneumococcal infection. Low levels of serum microRNA-223 correlated with increased disease severity in pneumococcal pneumonia patients. Prolonged neutrophilic influx into the lungs and alveolar spaces was detected in pneumococci-infected microRNA-223-knockout mice, possibly accounting for aggravated histopathology and acute lung injury. Expression of microRNA-223 in wild-type mice was induced by pneumococcal infection in a time-dependent manner in whole lungs and lung neutrophils. Single-cell transcriptome analyses of murine lungs revealed a unique profile of antimicrobial and cellular maturation genes that are dysregulated in neutrophils lacking microRNA-223. Taken together, low levels of microRNA-223 in human pneumonia patient serum were associated with increased disease severity, whilst its absence provoked dysregulation of the neutrophil transcriptome in murine pneumococcal pneumonia.
Improving cell-free glycoprotein synthesis by characterizing and enriching native membrane vesicles
Nucleic acid biomarkers of immune response and cell and tissue damage in children with COVID-19 and MIS-C - ScienceDirect
Cancers, Free Full-Text
Cell-free gene expression: an expanded repertoire of applications
Ds Kumar Strömungsmechanik Pdf Kostenloser Download - Colaboratory
Advances and applications of cell-free systems for metabolic production - ScienceDirect
Frontiers Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation
Cell-Free Gene Expression: Methods and Protocols
Cells, Free Full-Text
An integrated in vivo/in vitro framework to enhance cell-free biosynthesis with metabolically rewired yeast extracts
Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation
Rapid cell-free forward engineering of novel genetic ring oscillators
Cell-free mutant analysis combined with structure prediction of a lasso peptide biosynthetic protein B2
Cell-free synthesis of human interferon. - Abstract - Europe PMC
MitoQuicLy: A high-throughput method for quantifying cell-free DNA from human plasma, serum, and saliva - ScienceDirect
Recomendado para você
-
AeC - Relacionamento com Responsabilidade - Esse Robbyson chegou01 agosto 2024
-
Robbyson, o gestor de pessoas da AeC - Portal ClienteSA01 agosto 2024
-
Robbyson Belo Horizonte MG01 agosto 2024
-
Robbyson - Olá! Eu sou o Robbyson! A plataforma que chegou01 agosto 2024
-
Apresentação Startup Show - Reality Empreendedorismo01 agosto 2024
-
Robbyson Corporate Mobile by AeC Centro de Contatos SA01 agosto 2024
-
82 After Effects Medical Logo Stings Templates01 agosto 2024
-
CONAREC no LinkedIn: #conarec #conarec2023 #customerexperience #cx01 agosto 2024
-
Victor Frenay on Behance01 agosto 2024
-
Joana Azevedo - Líder de UX - Robbyson01 agosto 2024
você pode gostar
-
Resident Evil: Welcome to Raccoon City' Featurette Introduces01 agosto 2024
-
draw_kishibe on X: Ayanokoji Kiyotaka / Anime: Classroom Of Elite01 agosto 2024
-
Invisible NINJA Skin mod/hack INSANE KILLS! - Slither.io Gameplay01 agosto 2024
-
how to survive yellow in rainbow friends01 agosto 2024
-
Jogos xbox 360 bloqueado +712 anúncios na OLX Brasil01 agosto 2024
-
Microsoft Xbox One S 1TB All-Digital Edition Console (Disc-free Gaming) NJP-00024 - Best Buy01 agosto 2024
-
Rogue Company agora pode ser jogado de graça no PC, PS4, Xbox One e Switch01 agosto 2024
-
Rent-a-Girlfriend, Doblaje Wiki01 agosto 2024
-
20 Best Board Games on PC - The All-Time Favorites01 agosto 2024
-
St. Moriz Darker Than Dark 1 Hour Tan Review01 agosto 2024