Cells, Free Full-Text
Por um escritor misterioso
Last updated 11 julho 2024
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Cancer stem cells play a crucial role in tumor initiation, metastasis, and resistance to treatment. Cellular heterogeneity and plasticity complicate the isolation of cancer stem cells. The impact of intra-tumor cellular heterogeneity using a label-free approach remains understudied in the context of treatment resistance. Here, we use the sedimentation field–flow fractionation technique to separate, without labeling, cell subpopulations of colorectal cancer cell lines and primary cultures according to their biophysical properties. One of the three sorted cell subpopulations exhibits characteristics of cancer stem cells, including high tumorigenicity in vivo and a higher frequency of tumor-initiating cells compared to the other subpopulations. Due to its chemoresistance, two- and three-dimensional in vitro chemosensitivity assays highlight the therapeutic relevance of this cancer stem cell subpopulation. Thus, our results reveal the major implication of intra-tumor cellular heterogeneity, including cancer stem cells in treatment resistance, thanks to our label-free cell sorting approach. This approach enables—by breaking down the tumor—the study the individualized response of each sorted tumor cell subpopulation and to identify chemoresistance, thus offering new perspectives for personalized therapy.
![Cells, Free Full-Text](https://www.biorxiv.org/content/biorxiv/early/2022/04/06/2022.04.06.487251/F1.large.jpg)
Cell-free mutant analysis combined with structure prediction of a
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Cell-free expression and synthesis of viruses and bacteriophages
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Cell-free Fetal DNA — A Trigger for Parturition
![Cells, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2018/nejm_2018.379.issue-5/nejmra1705345/20181209/images/img_medium/nejmra1705345_f1.jpeg)
Sequencing of Circulating Cell-free DNA during Pregnancy
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Rapid cell-free forward engineering of novel genetic ring
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An integrated in vivo/in vitro framework to enhance cell-free
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Effect of calendar ageing on the cycle life of anode-free full
THE CELL : PAUL REVERE11 : Free Download, Borrow, and Streaming
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Cell-free metabolic engineering enables selective
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