IJMS, Free Full-Text
Por um escritor misterioso
Last updated 08 setembro 2024
![IJMS, Free Full-Text](https://www.mdpi.com/ijms/ijms-21-02533/article_deploy/html/images/ijms-21-02533-g001a.png)
Lysosomal storage disorders (LSDs) are predominantly very rare recessive autosomal neurodegenerative diseases.Sphingolipidoses, a sub-group of LSDs, result from defects in lysosomal enzymes involved in sphingolipid catabolism, and feature disrupted storage systems which trigger complex pathogenic cascades with other organelles collaterally affected. This process leads to cell dysfunction and death, particularly in the central nervous system. One valuable approach to gaining insights into the global impact of lysosomal dysfunction is through metabolomics, which represents a discovery tool for investigating disease-induced modifications in the patterns of large numbers of simultaneously-analysed metabolites, which also features the identification of biomarkers Here, the scope and applications of metabolomics strategies to the investigation of sphingolipidoses is explored in order to facilitate our understanding of the biomolecular basis of these conditions. This review therefore surveys the benefits of applying ’state-of-the-art’ metabolomics strategies, both univariate and multivariate, to sphingolipidoses, particularly Niemann-Pick type C disease. Relevant limitations of these techniques are also discussed, along with the latest advances and developments. We conclude that metabolomics strategies are highly valuable, distinctive bioanalytical techniques for probing LSDs, most especially for the detection and validation of potential biomarkers. They also show much promise for monitoring disease progression and the evaluation of therapeutic strategies and targets.
Ijms Free Full Text The Macrophages Microbiota Interplay In
![IJMS, Free Full-Text](https://pub.mdpi-res.com/ijms/ijms-13-16751/article_deploy/html/images/ijms-13-16751f1-1024.png?1403145310)
IJMS, Free Full-Text
![IJMS, Free Full-Text](https://www.researchgate.net/publication/331878760/figure/fig1/AS:774266643574784@1561610961410/Methods-of-hydrogel-synthesis-Examples-of-chemical-crosslinking-methods-and-physical.png)
IJMS Free Full-Text Research Advances In Mechanical, 52% OFF
![IJMS, Free Full-Text](https://www.mdpi.com/ijms/ijms-11-01509/article_deploy/html/images/ijms-11-01509f1-1024.png)
IJMS, Free Full-Text
Ijms Free Full Text Neural And Hormonal Basis Of 49680
![IJMS, Free Full-Text](https://pub.mdpi-res.com/polymers/polymers-15-01876/article_deploy/html/images/polymers-15-01876-g001.png?1681450031)
IJMS Free Full-Text Research Advances In Mechanical, 52% OFF
![IJMS, Free Full-Text](https://pub.mdpi-res.com/ijms/ijms-12-07114/article_deploy/html/images/ijms-12-07114f1-1024.png?1403143409)
IJMS, Free Full-Text
![IJMS, Free Full-Text](https://www.mdpi.com/ijms/ijms-14-05978/article_deploy/html/images/ijms-14-05978f1-1024.png)
IJMS, Free Full-Text
Ijms Free Full Text Neural And Hormonal Basis Of 49680
![IJMS, Free Full-Text](https://www.mdpi.com/ijms/ijms-16-13868/article_deploy/html/images/ijms-16-13868-g001-1024.png)
IJMS, Free Full-Text
![IJMS, Free Full-Text](https://pub.mdpi-res.com/ijms/ijms-15-21825/article_deploy/html/images/ijms-15-21825-g001-1024.png?1420571834)
IJMS, Free Full-Text
![IJMS, Free Full-Text](https://www.mdpi.com/ijms/ijms-23-15757/article_deploy/html/images/ijms-23-15757-g007.png)
IJMS Free Full-Text Research Advances In Mechanical, 54% OFF
Recomendado para você
-
Niemann-Pick disease type C: Video & Anatomy08 setembro 2024
-
Two-Year-Old Kamryn Living with Niemann-Pick Disease Type C (NPC) - The Children's Inn at NIH08 setembro 2024
-
Revista de Pediatria SOPERJ08 setembro 2024
-
Presentations of Niemann-Pick Type C disease08 setembro 2024
-
Laboratory diagnosis of Niemann-Pick disease type C: the filipin staining test.08 setembro 2024
-
Searching for a cure for Niemann-Pick Type C - NemaMetrix08 setembro 2024
-
Diagnostic workup and management of patients with suspected Niemann-Pick type C disease - Apostolos Papandreou, Paul Gissen, 201608 setembro 2024
-
Doença de Niemann-Pick – Wikipédia, a enciclopédia livre08 setembro 2024
-
Ohio 2-year-old battling rare Niemann-Pick disease, dubbed 'childhood Alzheimer's08 setembro 2024
-
The pathogenesis of Niemann–Pick type C disease: a role for autophagy?, Expert Reviews in Molecular Medicine08 setembro 2024
você pode gostar
-
Walkthrough - GoldenEye Guide - IGN08 setembro 2024
-
Rising Stars Concert at @universal.studios.orlando 12/9 It's Movie08 setembro 2024
-
Penang Chess Association08 setembro 2024
-
The Last of Us Is the Best Game of the Decade, According to Metacritic Users08 setembro 2024
-
Anime Club - River Heights Intermediate School08 setembro 2024
-
Episode 269: Avengers: End Game 'Time Loop Theory', Polar, FYRE08 setembro 2024
-
Chapter 130 (Preview) : r/bokunokokoro08 setembro 2024
-
Projeto de dispositivos mecânicos automatizados08 setembro 2024
-
Epic Spell Wars of the Battle Wizards: ANNIHILAGEDDON 2 by Cryptozoic Entertainment — Kickstarter08 setembro 2024
-
Advertising State-of-Play Report 202208 setembro 2024