Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Por um escritor misterioso
Last updated 13 julho 2024
Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
Protein synthesis as a modifiable target for autism‐related
Fragile X Mental Retardation Protein Induces Synapse Loss through
Which Comes First in Fragile X Syndrome, Dendritic Spine
Frontiers The Coordination of Local Translation, Membranous
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic
Frontiers The Use of Peptides in the Treatment of Fragile X
Fragile X Mental Retardation Protein Induces Synapse Loss through
Excess Translation of Epigenetic Regulators Contributes to Fragile
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis
Pten heterozygosity restores neuronal morphology in fragile X
Exaggerated protein synthesis in Fmr1 KO is ameliorated by mGluR5
Alzheimer's disease-related dysregulation of mRNA translation
The molecular biology of FMRP: new insights into fragile X
Altered mRNA transport, docking, and protein translation in
Molecular mechanisms behind mRNA localization in axons
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