Membranes, Free Full-Text
Por um escritor misterioso
Last updated 03 setembro 2024
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Synapse structures, including neuronal and immunological synapses, can be seen as the plasma membrane contact sites between two individual cells where information is transmitted from one cell to the other. The distance between the two plasma membranes is only a few tens of nanometers, but these areas are densely populated with functionally different proteins, including adhesion proteins, receptors, and transporters. The narrow space between the two plasma membranes has been a barrier for resolving the synaptic architecture due to the diffraction limit in conventional microscopy (~250 nm). Various advanced super-resolution microscopy techniques, such as stimulated emission depletion (STED), structured illumination microscopy (SIM), and single-molecule localization microscopy (SMLM), bypass the diffraction limit and provide a sub-diffraction-limit resolving power, ranging from 10 to 100 nm. The studies using super-resolution microscopy have revealed unprecedented details of the nanoscopic organization and dynamics of synaptic molecules. In general, most synaptic proteins appear to be heterogeneously distributed and form nanodomains at the membranes. These nanodomains are dynamic functional units, playing important roles in mediating signal transmission through synapses. Herein, we discuss our current knowledge on the super-resolution nanoscopic architecture of synapses and their functional implications, with a particular focus on the neuronal synapses and immune synapses.
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Improving cell-free glycoprotein synthesis by characterizing and
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Identification of electroporation sites in the complex lipid
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Second wave of INNOMEM OPEN CALLS NOW OPEN! » INNOMEM
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Membranes, Free Full-Text
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Lipid Organization of the Plasma Membrane
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Free-standing membrane incorporating single-atom catalysts for
Formation of solvent-free black lipid bilayer membranes from
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Activation energy for pore opening in lipid membranes under an
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Poster communication at 1º Encontro LEAF 2023 - CIEQV
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SRNF membranes for edible oil purification: Introducing free
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Membranes, Free Full-Text
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Membranes, Free Full-Text
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