Pathogens, Free Full-Text

Staphylococcus aureus causes many types of infections, ranging from self-resolving skin infections to severe or fatal pneumonia. Human innate immune cells, called polymorphonuclear leukocytes (PMNs or neutrophils), are essential for defense against S. aureus infections. Neutrophils are the most prominent cell type of the innate immune system and are capable of producing non-specific antimicrobial molecules that are effective at eliminating bacteria. Although significant progress has been made over the past few decades, our knowledge of S. aureus-host innate immune system interactions is incomplete. Most notably, S. aureus has the capacity to produce numerous molecules that are directed to protect the bacterium from neutrophils. Here we review in brief the role played by neutrophils in defense against S. aureus infection, and correspondingly, highlight selected S. aureus molecules that target key neutrophil functions.

Pathogens and Immunity

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Cell Host & Microbe on X: Microbiota-Driven Firewall Stops Pathogens: @BraedonMcdonald & Co show that pathogen clearance by Kupffer cells is governed by #gut #microbiota & D-lactate, which reaches liver via portal

PDF) Detection and characterization of zoonotic pathogens of free-ranging non-human primates from Zambia.

Pathogens, Free Full-Text

Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019 - The Lancet

Pathogens, Free Full-Text

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Frontiers Molecular Approaches for Low-Cost Point-of-Care Pathogen Detection in Agriculture and Forestry

Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm

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Read et al. warned us 2015 using chickens (Marek's disease) that using an imperfect 'leaky' vaccine can enhance transmission of highly virulent pathogens; sub-optimal non-sterilizing non-neutralizing

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