Pharmaceutics, Free Full-Text
Por um escritor misterioso
Last updated 14 julho 2024
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Viral and synthetic vectors to deliver nucleic acids were key to the rapid development of extraordinarily efficient COVID-19 vaccines. The four-component lipid nanoparticles (LNPs), containing phospholipids, PEG-conjugated lipids, cholesterol, and ionizable lipids, co-assembled with mRNA via a microfluidic technology, are the leading nonviral delivery vector used by BioNTech/Pfizer and Moderna to access COVID-19 mRNA vaccines. LNPs exhibit a statistical distribution of their four components when delivering mRNA. Here, we report a methodology that involves screening libraries to discover the molecular design principles required to realize organ-targeted mRNA delivery and mediate activity with a one-component ionizable multifunctional amphiphilic Janus dendrimer (IAJD) derived from plant phenolic acids. IAJDs co-assemble with mRNA into monodisperse dendrimersome nanoparticles (DNPs) with predictable dimensions, via the simple injection of their ethanol solution in a buffer. The precise location of the functional groups in one-component IAJDs demonstrated that the targeted organs, including the liver, spleen, lymph nodes, and lung, are selected based on the hydrophilic region, while activity is associated with the hydrophobic domain of IAJDs. These principles, and a mechanistic hypothesis to explain activity, simplify the synthesis of IAJDs, the assembly of DNPs, handling, and storage of vaccines, and reduce price, despite employing renewable plant starting materials. Using simple molecular design principles will lead to increased accessibility to a large diversity of mRNA-based vaccines and nanotherapeutics.
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Monastic Pharmacy, Original Medical Print / Poster 1950s (history, medicine, apothecary, pharmaceutical, monks, church, herbs, monastery)
Journal of the American Pharmaceutical Association 1933-11: Vol 22 Iss 11 : Free Download, Borrow, and Streaming : Internet Archive
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Colistin and polymyxin B: A re-emergence – topic of research paper in Clinical medicine. Download scholarly article PDF and read for free on CyberLeninka open science hub.
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QbD Application in Pharmaceutical Development for Nano Formulation – Quality by Design for Biotech, Pharmaceutical and Medical Devices
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Pharmaceuticals: Medical Science and Medical Industry. The Formation of the American Pharmaceutical Industry. Jonathan Liebenau. Johns Hopkins University Press, Baltimore, MD, 1987. x, 207 pp. $35. Henry E. Sigerist Series in the
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