The Safety of High Dose Labetalol in the Pregnant Population

Hypertension in pregnancy is one of the leading causes of maternal mortality and rapid treatment is critical. Treatment of emergent hypertensive crises in pregnancy is limited to only three medications, one of which is labetalol. Current literature recommends a daily maximum intravenous labetalol dose of 300 mg per day. However, this maximum dose has not been studied in pregnancy where higher doses may be required.

Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial - The Lancet

A COMPARATIVE RANDOMISED CONTROLLED PARALLEL GROUP STUDY OF EFFICACY AND TOLERABILITY OF LABETALOL VERSUS METHYLDOPA IN THE TREATMENT OF NEW ONSET HYPERTENSION DURING PREGNANCY

Chapter 10. Hypertension in women

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Nifedipine In Pregnancy: Safety, Usage, Dosage And Side Effects

Labetalol Hydrochloride Injection USP Taj Pharma SmPC by QC TAJ PHARMA - Issuu

Trial of Intrapartum Extended-Release Nifedipine to Prevent Severe Hypertension Among Pregnant Individuals With Preeclampsia With Severe Features

The vital signs and the cumulative labetalol dose over time. MAP = mean

A COMPARATIVE RANDOMISED CONTROLLED PARALLEL GROUP STUDY OF EFFICACY AND TOLERABILITY OF LABETALOL VERSUS METHYLDOPA IN THE TREATMENT OF NEW ONSET HYPERTENSION DURING PREGNANCY

relatively safe antihypertensive drugs in pregnancy

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Frontiers Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes