Vaccines, Free Full-Text
Por um escritor misterioso
Last updated 06 agosto 2024
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The ideal vaccine against viral infections should elicit antibody responses that protect against divergent strains. Designing broadly protective vaccines against SARS-CoV-2 and other divergent viruses requires insight into the specific targets of cross-protective antibodies on the viral surface protein(s). However, unlike therapeutic monoclonal antibodies, the B-cell epitopes of vaccine-induced polyclonal antibody responses remain poorly defined. Here we show that, through the combination of neutralizing antibody functional responses with B-cell epitope mapping, it is possible to identify unique antibody targets associated with neutralization breadth. The polyclonal antibody profiles of SARS-CoV-2 index-strain-vaccinated rabbits that demonstrated a low, intermediate, or high neutralization efficiency of different SARS-CoV-2 variants of concern (VOCs) were distinctly different. Animals with an intermediate and high cross-neutralization of VOCs targeted fewer antigenic sites on the spike protein and targeted one particular epitope, subdomain 1 (SD1), situated outside the receptor binding domain (RBD). Our results indicate that a targeted functional antibody response and an additional focus on non-RBD epitopes could be effective for broad protection against different SARS-CoV-2 variants. We anticipate that the approach taken in this study can be applied to other viral vaccines for identifying future epitopes that confer cross-neutralizing antibody responses, and that our findings will inform a rational vaccine design for SARS-CoV-2.
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Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against
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Appeals to community spirit, shame most likely to shift vaccine
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ASIIS-Web Main Page
Framework for Equitable Allocation of COVID-19 Vaccine
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Fourth Dose of BNT162b2 mRNA Covid-19 Vaccine in a Nationwide
![Vaccines, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2020/nejm_2020.383.issue-27/nejmoa2034577/20210819/images/img_medium/nejmoa2034577_f0.jpeg)
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
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Frontiers Predictors of COVID-19 Vaccine Acceptance, Intention
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FAQs: Vaccines Department of Health website
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Information and facts about about COVID-19 vaccines Archives
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World leaders unite in call for a people's vaccine against COVID
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Vaccines, Free Full-Text
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