Viruses, Free Full-Text
Por um escritor misterioso
Last updated 12 julho 2024
![Viruses, Free Full-Text](https://pub.mdpi-res.com/viruses/viruses-15-01744/article_deploy/html/images/viruses-15-01744-g001.png?1692084236)
The successful development of a chemoprophylaxis against SARS-CoV-2 could provide a tool for infection prevention that is implementable alongside vaccination programmes. Nafamostat is a serine protease inhibitor that inhibits SARS-CoV-2 entry in vitro, but it has not been characterised for chemoprophylaxis in animal models. Clinically, nafamostat is limited to intravenous delivery and has an extremely short plasma half-life. This study sought to determine whether intranasal dosing of nafamostat at 5 mg/kg twice daily was able to prevent the airborne transmission of SARS-CoV-2 from infected to uninfected Syrian Golden hamsters. SARS-CoV-2 RNA was detectable in the throat swabs of the water-treated control group 4 days after cohabitation with a SARS-CoV-2 inoculated hamster. However, throat swabs from the intranasal nafamostat-treated hamsters remained SARS-CoV-2 RNA negative for the full 4 days of cohabitation. Significantly lower SARS-CoV-2 RNA concentrations were seen in the nasal turbinates of the nafamostat-treated group compared to the control (p = 0.001). A plaque assay quantified a significantly lower concentration of infectious SARS-CoV-2 in the lungs of the nafamostat-treated group compared to the control (p = 0.035). When taken collectively with the pathological changes observed in the lungs and nasal mucosa, these data are strongly supportive of the utility of intranasally delivered nafamostat for the prevention of SARS-CoV-2 infection.
![Viruses, Free Full-Text](https://media.muckrack.com/profile/images/511021/tiffany-hu.jpeg.256x256_q100_crop-smart.jpg)
Articles by Tiffany Hu's Profile, Law360 Journalist
![Viruses, Free Full-Text](https://www.hostinger.com/tutorials/wp-content/uploads/sites/2/2022/12/Malware-Scanner-tool-in-hPanel.webp)
How to Check a Website for Viruses: 6 Methods
![Viruses, Free Full-Text](https://www.wikihow.com/images/thumb/9/9b/Create-a-Virus-Step-1-Version-3.jpg/v4-460px-Create-a-Virus-Step-1-Version-3.jpg.webp)
How to Create a Virus: 9 Steps (with Pictures) - wikiHow
![Viruses, Free Full-Text](https://i.fbcd.co/products/resized/resized-750-500/2201-m04-i035-n014-mainpreview-78f88e84842600200e4115ccd96e93cefd1fbb404b497b6bbb3d08c6be0a8fd0.jpg)
Cartoon viruses. Germs virus character, funny bacteria types
![Viruses, Free Full-Text](https://www.mdpi.com/viruses/viruses-04-01438/article_deploy/html/images/viruses-04-01438-g002-1024.png)
Viruses, Free Full-Text
![Viruses, Free Full-Text](https://ars.els-cdn.com/content/image/1-s2.0-S004896972201350X-ga1.jpg)
Capsid integrity detection of pathogenic viruses in waters: Recent progress and potential future applications - ScienceDirect
![Viruses, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2022/nejm_2022.387.issue-19/nejmra2208860/20221107/images/img_medium/nejmra2208860_f1.jpeg)
Monkeypox
![Viruses, Free Full-Text](https://www.mdpi.com/viruses/viruses-04-03363/article_deploy/html/images/viruses-04-03363-g002-1024.png)
Viruses, Free Full-Text
![Viruses, Free Full-Text](https://www.pcrisk.com/images/stories/screenshots201901/downloadingvirus-homepage.jpg)
Downloading Virus Trojan_horse.exe POP-UP Scam - Removal and recovery steps (updated)
![Viruses, Free Full-Text](https://onlinelibrary.wiley.com/cms/asset/77591de3-8163-4704-aa78-e8f246facf12/jvh12619-toc-0001-m.jpg)
Journal of Viral Hepatitis
Recomendado para você
-
The Hamster's Lifespan - 7 Things Affecting It12 julho 2024
-
Life Cycle of Hamsters12 julho 2024
-
Life Cycle of a Hamster by Amanda Inman on Prezi Next12 julho 2024
-
How I programmed a Virtual Hamster Cage blog - Gamieon - Mod DB12 julho 2024
-
Gerbil Life Cycle Gerbil, Baby hamster, Cute baby animals12 julho 2024
-
The Life Cycle of Hamsters - My Animals12 julho 2024
-
Hamsters in medical research12 julho 2024
-
Pathogens, Free Full-Text12 julho 2024
-
Age of Laboratory Hamster and Human: Drawing the Connexion - Document - Gale OneFile: Health and Medicine12 julho 2024
-
Hamster Care: The Ultimate Guide to Caring for Hamsters12 julho 2024
você pode gostar
-
MARVEL Strike Force” celebrates five years of community, teamwork12 julho 2024
-
Clube alemão lança camisa em homenagem a Oktoberfest12 julho 2024
-
Are there any ways to play chess with a friend online? - Quora12 julho 2024
-
The Church of the Nativity of Our Lord in St. Paul, Minnesota ~ Liturgical Arts Journal12 julho 2024
-
The Titan's Bride Anime Gets English Dub12 julho 2024
-
Anime Brawl Codes Wiki & Trello[UPDATE][December 2023] - MrGuider12 julho 2024
-
LuckyBlocks Mod - Addon for Android - Download12 julho 2024
-
Sons Of The Forest Pickaxe Location - MMO Wiki12 julho 2024
-
fyp only highschool so don't ode12 julho 2024
-
Volante da Mega Sena Download Scientific Diagram12 julho 2024