Replicatively senescent cells are arrested in G1 and G2 phases - Figure F1
Por um escritor misterioso
Last updated 07 julho 2024
Senescent human fibroblast cultures contain a large fraction of putative G2-arrested cells with 4N DNA content. (A) Propidium iodide (PI) staining and flow cyctometric analysis of HCA2 normal human foreskin fibroblasts. Cells entered senescence at PD73. (B) PI staining of replicatively senescent human lung fibroblasts WI-38, and IMR-90 at PDs 73 and 68 respectively. (C) The fraction of 4N cells in senescent cell population does not diminish with time. Replicatively senescent HCA2 cells were analyzed by PI staining at weekly intervals for 10 weeks stating from the onset of senescence.
![Replicatively senescent cells are arrested in G1 and G2 phases - Figure F1](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41420-018-0123-9/MediaObjects/41420_2018_123_Fig4_HTML.png)
Cell cycle shift from G0/G1 to S and G2/M phases is responsible
MicroRNA-152 and -181a participate in human dermal fibroblasts
![Replicatively senescent cells are arrested in G1 and G2 phases - Figure F1](https://www.spandidos-publications.com/article_images/ijo/43/1/IJO-43-01-0289-g04.jpg)
Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53
![Replicatively senescent cells are arrested in G1 and G2 phases - Figure F1](https://ars.els-cdn.com/content/image/1-s2.0-S1097276514003979-fx1.jpg)
Necessary and Sufficient Role for a Mitosis Skip in Senescence
![Replicatively senescent cells are arrested in G1 and G2 phases - Figure F1](https://www.researchgate.net/publication/306132098/figure/fig1/AS:395690174894085@1471351297671/Senescent-BT-20-cells-with-PRL-3-knockdown-arrest-in-G1-despite-unique-cell-cycle.png)
Senescent BT-20 cells with PRL-3 knockdown arrest in G1 despite
![Replicatively senescent cells are arrested in G1 and G2 phases - Figure F1](https://www.frontiersin.org/files/Articles/588050/fcell-08-588050-HTML/image_m/fcell-08-588050-g004.jpg)
Frontiers Reversed Senescence of Retinal Pigment Epithelial Cell
![Replicatively senescent cells are arrested in G1 and G2 phases - Figure F1](https://www.biorxiv.org/content/biorxiv/early/2022/07/13/2022.07.12.499783/F6.large.jpg)
Cellular senescence preserves viral genome maintenance
![Replicatively senescent cells are arrested in G1 and G2 phases - Figure F1](https://www.spandidos-publications.com/article_images/mco/12/1/mco-12-01-0009-g01.jpg)
Induction of G0/G1 phase arrest and apoptosis by CRISPR/Cas9
![Replicatively senescent cells are arrested in G1 and G2 phases - Figure F1](https://www.biorxiv.org/content/biorxiv/early/2021/08/17/2021.08.17.452482/F13.large.jpg)
Reciprocal regulation of p21 and Chk1 controls the Cyclin D1-RB
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