Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1
Por um escritor misterioso
Last updated 01 setembro 2024
![Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41408-023-00826-6/MediaObjects/41408_2023_826_Fig1_HTML.png)
![Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1](https://febs.onlinelibrary.wiley.com/cms/asset/df5b12ed-a4b7-47e0-b833-df8f4df87072/febs16268-fig-0003-m.jpg)
Molecular regulators of HOXA9 in acute myeloid leukemia - Aryal
![Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1](https://europepmc.org/articles/PMC8752621/bin/41408_2021_603_Fig7_HTML.jpg)
Effective Menin inhibitor-based combinations against AML with MLL
![Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1](https://www.frontiersin.org/files/MyHome%20Article%20Library/972606/972606_Thumb_400.jpg)
Frontiers Targeted therapy in NPM1-mutated AML: Knowns and unknowns
![Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/ab268740-8613-4974-a142-4340bcd12c40/cmdc202000972-toc-0001-m.png)
A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene
![Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41375-023-01882-4/MediaObjects/41375_2023_1882_Fig1_HTML.png)
Causal linkage of presence of mutant NPM1 to efficacy of novel
![Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1](https://i.oaes.cc/images_2018/journals/forabstract/cdr/4740.png)
Venetoclax resistance: mechanistic insights and future strategies
![Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1](https://www.researchgate.net/publication/351745947/figure/fig5/AS:1025776593932289@1621575606272/Co-treatment-with-LSD1i-and-BET-inhibitor-BETi-or-ruxolitinib-exerts-synergistic-lethal.png)
Co-treatment with LSD1i and BET inhibitor (BETi) or ruxolitinib
![Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1](https://www.researchgate.net/publication/350663374/figure/fig1/AS:11431281116315462@1675223957679/MLL1-and-oncogenic-MLL1-fusion-proteins-a-Illustrations-of-MLL1-and-onco-MLL1-fusion.png)
MLL1 and oncogenic MLL1 fusion proteins. a Illustrations of MLL1
![Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41375-022-01666-2/MediaObjects/41375_2022_1666_Fig5_HTML.png)
Current status and future perspectives in targeted therapy of NPM1
![Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41586-023-05812-3/MediaObjects/41586_2023_5812_Fig1_HTML.png)
The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant
![Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41408-021-00487-3/MediaObjects/41408_2021_487_Fig1_HTML.png)
Superior efficacy of co-targeting GFI1/KDM1A and BRD4 against AML
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