Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin
Por um escritor misterioso
Last updated 02 setembro 2024
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://www.pnas.org/cms/10.1073/pnas.2200102119/asset/66743438-dcd1-47a6-bfa8-656e54bac69e/assets/images/large/pnas.2200102119fig01.jpg)
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://ars.els-cdn.com/content/image/1-s2.0-S0006295223002927-gr6.jpg)
Alpha-2-macroglobulin prevents platelet aggregation induced by
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://www.mdpi.com/biophysica/biophysica-03-00041/article_deploy/html/images/biophysica-03-00041-g005-550.jpg)
Biophysica, Free Full-Text
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://www.pnas.org/cms/10.1073/pnas.2200102119/asset/bcfe05a5-3dd1-4d6e-9b86-a3d71cfaedec/assets/images/large/pnas.2200102119fig07.jpg)
Cryo-EM structures show the mechanistic basis of pan-peptidase
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://cdn.rcsb.org/images/structures/7o7m_model-1.jpeg)
RCSB PDB - 7O7M: (h-alpha2M)4 native II
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://i1.rgstatic.net/publication/17017903_Clearance_and_binding_of_two_electrophoretic_'fast'_forms_of_a2-macroglobulin/links/00b7d524a2341aea52000000/largepreview.png)
PDF) Clearance and binding of two electrophoretic 'fast' forms of
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41598-023-31104-x/MediaObjects/41598_2023_31104_Fig7_HTML.png)
Alpha 2-macroglobulin acts as a clearance factor in the lysosomal
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://ars.els-cdn.com/content/image/1-s2.0-S0006295223002927-gr7.jpg)
Alpha-2-macroglobulin prevents platelet aggregation induced by
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://europepmc.org/articles/PMC8167298/bin/gr2.jpg)
Structural Investigations of Human A2M Identify a Hollow Native
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://files.wwpdb.org/pub/emdb/structures/EMD-12747/images/emd_12747.png)
EMDR : EMD-12747
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://pubs.acs.org/cms/10.1021/acs.jproteome.2c00323/asset/images/large/pr2c00323_0007.jpeg)
Quantifying In Situ Structural Stabilities of Human Blood Plasma
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://www.pnas.org/cms/asset/43b767b9-d360-428d-b184-0446c67275d4/keyimage.jpg)
Cryo-EM structures show the mechanistic basis of pan-peptidase
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://www.researchgate.net/publication/354835133/figure/fig1/AS:1072306491232259@1632669198690/2D-and-3D-structures-of-the-A2Moo-tetramers-A-Representative-2D-class-averages-of-the_Q320.jpg)
PDF) Structural Mechanics of the Alpha-2-Macroglobulin Transformation
![Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin](https://www.pnas.org/cms/10.1073/pnas.1506538112/asset/55c7452f-59f4-4e66-8973-2f5da11edb71/assets/graphic/pnas.1506538112fig01.jpeg)
Structural and functional insights into Escherichia coli α2
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