A new synonym-substitution method to enrich the human phenotype
Por um escritor misterioso
Last updated 05 julho 2024
![A new synonym-substitution method to enrich the human phenotype](https://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12859-017-1858-7/MediaObjects/12859_2017_1858_Fig3_HTML.gif)
Background Named entity recognition is critical for biomedical text mining, where it is not unusual to find entities labeled by a wide range of different terms. Nowadays, ontologies are one of the crucial enabling technologies in bioinformatics, providing resources for improved natural language processing tasks. However, biomedical ontology-based named entity recognition continues to be a major research problem. Results This paper presents an automated synonym-substitution method to enrich the Human Phenotype Ontology (HPO) with new synonyms. The approach is mainly based on both the lexical properties of the terms and the hierarchical structure of the ontology. By scanning the lexical difference between a term and its descendant terms, the method can learn new names and modifiers in order to generate synonyms for the descendant terms. By searching for the exact phrases in MEDLINE, the method can automatically rule out illogical candidate synonyms. In total, 745 new terms were identified. These terms were indirectly evaluated through the concept annotations on a gold standard corpus and also by document retrieval on a collection of abstracts on hereditary diseases. A moderate improvement in the F-measure performance on the gold standard corpus was observed. Additionally, 6% more abstracts on hereditary diseases were retrieved, and this percentage was 33% higher if only the highly informative concepts were considered. Conclusions A synonym-substitution procedure that leverages the HPO hierarchical structure works well for a reliable and automatic extension of the terminology. The results show that the generated synonyms have a positive impact on concept recognition, mainly those synonyms corresponding to highly informative HPO terms.
![A new synonym-substitution method to enrich the human phenotype](https://www.researchgate.net/profile/M-Taboada/publication/320314449/figure/fig2/AS:548988971479041@1507900578694/Example-of-synonymy-generated-by-our-method-On-the-left-side-a-very-small-excerpt-of_Q320.jpg)
PDF) A new synonym-substitution method to enrich the human
![A new synonym-substitution method to enrich the human phenotype](https://media.springernature.com/m685/springer-static/image/art%3A10.1186%2Fs12859-017-1858-7/MediaObjects/12859_2017_1858_Fig6_HTML.gif)
A new synonym-substitution method to enrich the human phenotype
![A new synonym-substitution method to enrich the human phenotype](https://www.researchgate.net/profile/M-Taboada/publication/320314449/figure/tbl1/AS:668805860708354@1536467151310/Metrics-used-for-the-lexical-overlaps-in-HPO_Q320.jpg)
PDF) A new synonym-substitution method to enrich the human
![A new synonym-substitution method to enrich the human phenotype](https://www.macmillanhighered.com/BrainHoney/Resource/6716/digital_first_content/trunk/test/hillis2e/asset/img_ch15/c15_fig17.jpg)
hillis2e_ch15
![A new synonym-substitution method to enrich the human phenotype](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fnrg3051/MediaObjects/41576_2011_Article_BFnrg3051_Fig1_HTML.jpg)
Understanding the contribution of synonymous mutations to human
![A new synonym-substitution method to enrich the human phenotype](https://c5.rgstatic.net/m/4671872220764/images/template/default/profile/profile_default_m.jpg)
PDF) A new synonym-substitution method to enrich the human
![A new synonym-substitution method to enrich the human phenotype](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41586-022-05028-x/MediaObjects/41586_2022_5028_Fig1_HTML.png)
A physical wiring diagram for the human immune system
![A new synonym-substitution method to enrich the human phenotype](https://www.genome.gov/sites/default/files/media/images/tg/Subsitution.jpg)
Substitution
![A new synonym-substitution method to enrich the human phenotype](https://www.researchgate.net/publication/265298388/figure/tbl4/AS:601752386674701@1520480357273/Sample-of-synonyms-found-by-our-system-in-SNOMED-CT.png)
Sample of synonyms found by our system in SNOMED-CT
![A new synonym-substitution method to enrich the human phenotype](https://www.pnas.org/cms/10.1073/pnas.2218835120/asset/ce3e5c39-2824-4ca1-b68d-4e083f9d36e2/assets/images/large/pnas.2218835120fig01.jpg)
Whole-genome sequences from wild-type and laboratory-evolved
The text mining experiment workflow to answer the question what
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