Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science
Por um escritor misterioso
Last updated 10 julho 2024
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2F1423-0127-18-86/MediaObjects/12929_2011_Article_342_Fig1_HTML.jpg)
Background Osteoarthritis (OA) is characterized by the degradation of articular cartilage, marked by the breakdown of matrix proteins. Studies demonstrated the involvement of chemokines in this process, and some may potentially serve as diagnostic markers and therapeutic targets; however, the underlying signal transductions are not well understood. Methods We investigated the effects of the CC chemokine eotaxin-1 (CCL11) on the matrix metalloproteinase (MMP) expression and secretion in the human chondrocyte cell line SW1353 and primary chondrocytes. Results Eotaxin-1 significantly induced MMP-3 mRNA expression in a dose-dependent manner. Inhibitors of extracellular signal-regulated kinase (ERK) and p38 kinase were able to repress eotaxin-1-induced MMP-3 expression. On the contrary, Rp-adenosine-3',5'-cyclic monophosphorothioate (Rp-cAMPs), a competitive cAMP antagonist for cAMP receptors, and H-89, a protein kinase A (PKA) inhibitor, markedly enhanced eotaxin-1-induced MMP-3 expression. These results suggest that MMP-3 expression is specifically mediated by the G protein-coupled eotaxin-1 receptor activities. Interestingly, little amount of MMP-3 protein was detected in the cell lysates of eotaxin-1-treated SW1353 cells, and most of MMP-3 protein was in the culture media. Furthermore we found that the eotaxin-1-dependent MMP-3 protein secretion was regulated by phospholipase C (PLC)-protein kinase C (PKC) cascade and c-Jun N-terminal kinase (JNK)/mitogen-activated protein (MAP) kinase pathways. These data indicate a specific regulation of MMP-3 secretion also by eotaxin-1 receptor activities. Conclusions Eotaxin-1 not only induces MMP-3 gene expression but also promotes MMP-3 protein secretion through G protein-coupled eotaxin-1 receptor activities. Chemokines, such as eotaxin-1, could be a potential candidate in the diagnosis and treatment of arthritis.
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41413-023-00248-x/MediaObjects/41413_2023_248_Fig1_HTML.png)
Mechanotransduction pathways in articular chondrocytes and the emerging role of estrogen receptor-α
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://pub.mdpi-res.com/molecules/molecules-28-05426/article_deploy/html/images/molecules-28-05426-g002.png?1689589089)
Molecules, Free Full-Text
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://ars.els-cdn.com/content/image/1-s2.0-S0091674918307097-fx1.jpg)
Novel peptide nanoparticle–biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness - ScienceDirect
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://ars.els-cdn.com/content/image/1-s2.0-S1063458415000618-gr4.jpg)
Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes - ScienceDirect
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://pathsocjournals.onlinelibrary.wiley.com/cms/asset/d6fac634-fd80-46c7-ba07-3b68052b46d5/path5013-fig-0005-m.jpg)
Interleukin‐17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis - Singh - 2018 - The Journal of Pathology - Wiley Online Library
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://journals.physiology.org/cms/10.1152/physrev.00022.2006/asset/images/medium/z9j0010724210004.jpeg)
Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41598-021-01063-2/MediaObjects/41598_2021_1063_Fig5_HTML.png)
Basal and IL-1β enhanced chondrocyte chemotactic activity on monocytes are co-dependent on both IKKα and IKKβ NF-κB activating kinases
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs10753-019-01037-7/MediaObjects/10753_2019_1037_Fig3_HTML.png)
Garcinol Suppresses IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via Inhibition of the NF-κB Signaling Pathway
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://journals.physiology.org/cms/10.1152/physrev.00028.2021/asset/images/medium/prv-00028-2021r01.png)
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://www.mdpi.com/nanomaterials/nanomaterials-04-00485/article_deploy/html/images/nanomaterials-04-00485-g003.png)
Nanomaterials, Free Full-Text
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://media.springernature.com/m685/springer-static/image/art%3A10.1186%2F1423-0127-18-86/MediaObjects/12929_2011_Article_342_Fig7_HTML.jpg)
Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science
![Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes, Journal of Biomedical Science](https://journals.sagepub.com/cms/10.1177/2040622312462734/asset/images/large/10.1177_2040622312462734-fig2.jpeg)
New findings in osteoarthritis pathogenesis: therapeutic implications - Lia Pulsatelli, Olga Addimanda, Veronica Brusi, Branka Pavloska, Riccardo Meliconi, 2013
Recomendado para você
-
Most Disturbed Person on Planet Earth III (2019) - IMDb10 julho 2024
-
Most Disturbed Person on Planet Earth Part 2: Review von Staub ()10 julho 2024
-
i watched most disturbed person on planet earth (MDPOPE) so you don't have to, because you shouldn't10 julho 2024
-
Most Disturbed Person on Planet Earth (2013) - IMDb10 julho 2024
-
Disturbing Movies Iceberg - Page 210 julho 2024
-
Cancers, Free Full-Text10 julho 2024
-
MDPOPE โคตรหนังโหดของสายแข็งสุดขั้ว10 julho 2024
-
Terra Insanus by Edward Lee10 julho 2024
-
Tule elk selection of surface water and forage is mediated by season and drought – California Fish and Wildlife Scientific Journal10 julho 2024
-
Micromachines, Free Full-Text10 julho 2024
você pode gostar
-
Kawaii FNAF Five Nights at Freddy's Plush Toys Nightmare Fredbear Freddy Stuffed Toys Doll 30Cm Dpprdl : : Sports & Outdoors10 julho 2024
-
Read Kenja No Deshi Wo Nanoru Kenja Chapter 46 - MangaFreak10 julho 2024
-
Feral Stick Figures | Sticker10 julho 2024
-
War Hippies, Scooter Brown & Donnie Reis10 julho 2024
-
Nissa Kumala: música, letras, canciones, discos10 julho 2024
-
Boneca Dc Super Hero Girls - Harley Quinn MATTEL10 julho 2024
-
Credit Union & Bank Drive-Thru Equipment10 julho 2024
-
Pou sigma10 julho 2024
-
RoNew10 julho 2024
-
the gamejolt website has a internal server error · Issue #1476 · gamejolt/issue-tracker · GitHub10 julho 2024