Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer
Por um escritor misterioso
Last updated 05 setembro 2024
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs12885-023-10501-5/MediaObjects/12885_2023_10501_Fig3_HTML.png)
Background The link between immediate hypersensitivity reactions (HSR) following the first cetuximab infusion and the IgE sensitization against anti-galactose-α-1,3-galactose (α-Gal) is now well-established. An automated Fluoroenzyme-Immunoassay (FEIA) is available and may facilitate the screening of patients with anti-α-Gal IgE before treatment. Methods This study aimed to evaluate its performances as compared to a previously validated anti-cetuximab IgE ELISA, using 185 samples from two previously studied cohorts. Results Despite 21.1% of discrepancies between the two techniques, FEIA discriminated better positive patients and similarly negative ones with a ≥ 0.525 kUA/L threshold. Sensitivity was 87.5% for both tests, specificity was better for FEIA (96.3% vs ELISA: 82.1%). FEIA had a higher positive likelihood ratio (23.9 vs ELISA: 4.89) and a similar negative likelihood ratio (0.13 vs ELISA: 0.15). In our population, the risk of severe HSR following a positive test was higher with FEIA (56.7% vs ELISA: 19.6%) and similar following a negative test (0.7% vs ELISA: 0.8%). Conclusion Although the predictive value of the IgE screening before cetuximab infusion remains discussed, this automated commercial test can identify high-risk patients and is suitable for routine use in laboratories. It could help avoiding cetuximab-induced HSR by a systematic anti-α-Gal IgE screening before treatment.
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41586-020-2311-z/MediaObjects/41586_2020_2311_Fig1_HTML.png)
Sialylation of immunoglobulin E is a determinant of allergic pathogenicity
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://www.researchgate.net/publication/332771719/figure/tbl1/AS:873418165600257@1585250526389/Japanese-cases-of-cetuximab-induced-anaphylactic-shock_Q320.jpg)
PDF) Alpha-Gal-containing biologics and anaphylaxis
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://www.researchgate.net/publication/346677178/figure/fig1/AS:966074644316162@1607341552634/The-flowchart-of-the-studies-included-in-this-meta-analysis_Q320.jpg)
The flowchart of the studies included in this meta-analysis.
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://ars.els-cdn.com/content/image/1-s2.0-S0091674918303087-fx1.jpg)
Mast cell activation test in the diagnosis of allergic disease and anaphylaxis - ScienceDirect
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://www.researchgate.net/publication/352693335/figure/fig1/AS:1037919531839488@1624470708111/Number-of-cetuximab-prescription-over-time_Q320.jpg)
PDF) Nationwide pharmacovigilance data for cetuximab-induced anaphylaxis and predictive model validation using prospective specific IgE detection
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs40521-019-00207-0/MediaObjects/40521_2019_207_Fig1_HTML.png)
Anaphylaxis Induced by Biologics Current Treatment Options in Allergy
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://www.researchgate.net/publication/282772359/figure/tbl2/AS:614173541150735@1523441791499/HPV-positive-and-HPV-negative-HNSCC-molecular-profiles_Q320.jpg)
Prevalence of anti-cetuximab IgE. IgE levels were measured in serum
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://www.liebertpub.com/cms/10.1089/jir.2012.0139/asset/images/medium/figure3.gif)
Manifestations of Antidrug Antibodies Response: Hypersensitivity and Infusion Reactions
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs40521-022-00326-1/MediaObjects/40521_2022_326_Fig1_HTML.png)
New Biomarkers in Anaphylaxis (Beyond Tryptase)
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1476-7961-10-5/MediaObjects/12948_2011_Article_105_Fig4_HTML.jpg)
Anaphylactic Reactions to Oligosaccharides in Red Meat: a Syndrome in Evolution, Clinical and Molecular Allergy
![Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab, BMC Cancer](https://i1.rgstatic.net/publication/264462937_Case_Report_About_Fatal_or_Near-Fatal_Hypersensitivity_Reactions_to_Cetuximab_Anticetuximab_IgE_as_a_Valuable_Screening_Test/links/6429a60066f8522c38f03562/largepreview.png)
(PDF) Case Report About Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test
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