Biomedicines, Free Full-Text
Por um escritor misterioso
Last updated 29 julho 2024
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Alpha-synuclein’s role in diseases termed “synucleinopathies”, including Parkinson’s disease, has been well-documented. However, after over 25 years of research, we still do not fully understand the alpha-synuclein protein and its role in disease. In vitro cellular models are some of the most powerful tools that researchers have at their disposal to understand protein function. Advantages include good control over experimental conditions, the possibility for high throughput, and fewer ethical issues when compared to animal models or the attainment of human samples. On the flip side, their major disadvantages are their questionable relevance and lack of a “whole-brain” environment when it comes to modeling human diseases, such as is the case of neurodegenerative disorders. Although now, with the advent of pluripotent stem cells and the ability to create minibrains in a dish, this is changing. With this review, we aim to wade through the recent alpha-synuclein literature to discuss how different cell culture setups (immortalized cell lines, primary neurons, human induced pluripotent stem cells (hiPSCs), blood–brain barrier models, and brain organoids) can help us understand aggregation pathology in Parkinson’s and other synucleinopathies.
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Full article: Promising Natural Products in New Drug Design
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Povyk sloužit hlavní, důležitý exosomes metastases and the miracle
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Catalytically Active Snake Venom PLA2 Enzymes: An Overview of Its
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Frontiers Metabolic Disruption by Naturally Occurring Mycotoxins
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Biomedicines, Free Full-Text
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Biomedicines An Open Access Journal from MDPI
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Caloric restriction in humans reveals immunometabolic regulators
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Biomedicines An Open Access Journal from MDPI
Biomedicines, Free Full-Text
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Assessing production variability in empty and filled adeno
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Generate: Biomedicines - Fonts In Use
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Decoding the Patterns of Self and Nonself by the Innate Immune
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